Bio-Inspired Proanthocyanidins from Blueberries’ Surface Coating Prevents Red Blood Cell Agglutination on Urinary Silicon-Based Catheters

Thrombosis can cause the occlusion of implantable medical devices, leading to rejection device and subsequent mortality. is primarily induced by red blood aggregation coagulation. The administration anticoagulant drugs generally used as a treatment avoid these processes. Adverse effects such bleeding in event an overdose, osteoporosis associated with prolonged use, hypersensitivity, hives have been reported. New strategies biomolecule surface functionalization recently studied overcome problems. In this study, we report novel coating composed polydopamine (PDA) proanthocyanidins (PACs) from blueberry extract short-term use devices silicone catheters. We showed that PDA formed stable films on surfaces PACs could be immobilized layers using laccase catalyst. PDA–PACs decreased hydrophilicity, increased roughness, plasma protein adsorption. were phosphate buffer saline (PBS) cell culture media. Furthermore, adsorption decreased. These are attributed changes membrane fluidity influences adhesion, steric hindrance layers, low proteins PAC layer.